The association between Down's syndrome (DS) and Alzheimer's disease is wel
l established. This paper presents a review of the literature, suggesting a
possible association between DS and the more recently recognised dementia
with Lewy bodies (DLB). Patients with DLB frequently present with changes i
n affect and behaviour, and in particular with psychotic symptoms. The lite
rature suggests a possible role for atypical neuroleptics in the management
of psychosis in DLB. Copyright (C) 2001 John Wiley & Sons, Ltd.