Background We describe a young woman who presented with minor stroke a
s a first clinical symptom of Sjogren's syndrome (SS) in the absence o
f well-known risk factors for cerebrovascular disease. Case Descriptio
n The medical history included recurrent miscarriages and sun rashes,
which directed the diagnosis toward immunologic disorders such as syst
emic lupus erythematosus and antiphospholipid antibody syndrome, which
are often associated with stroke. Only complete laboratory testing, i
ncluding SSB antibody studies, and ophthalmologic and salivary gland e
valuation revealed the correct diagnosis. Conclusions Sjogren's syndro
me should be considered among the causes of stroke, especially in a yo
ung female patient.