J. Iwahashi et al., Isolation of amantadine-resistant influenza A viruses (H3N2) from patientsfollowing administration of amantadine in Japan, J CLIN MICR, 39(4), 2001, pp. 1652-1653
In Japan, the use of amantadine for treatment of influenza A virus infectio
n was not accepted until November 1998, although it was widely used for tre
atment of Parkinsonism. Since then, we have monitored the emergence of aman
tadine-resistant viruses and isolated two viruses from patients on long-ter
m treatment with amantadine.