Solution phase synthesis of libraries of variably substituted olefin scaffolds: A library of allylic amines

Authors
Organ, MG Mayhew, D Cooper, JT Dixon, CE Lavorato, DJ Kaldor, SW Siegel, MG
Citation
Mg. Organ et al., Solution phase synthesis of libraries of variably substituted olefin scaffolds: A library of allylic amines, J COMB CHEM, 3(1), 2001, pp. 64-67
Citations number
24
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
64 - 67
Database
ISI
SICI code
1520-4766(200101/02)3:1<64:SPSOLO>2.0.ZU;2-R
Abstract
The synthesis of allylic amine libraries derived from olefin templates is d escribed. The two-step, solution phase reaction sequence consists of aminat ion of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesiz e a 1344-member allylic amine library.