Kolmogorov's equation, which relates second- and third-order moments of the
velocity increment, provides a simple method for estimating the mean energ
y dissipation rate [epsilon] for homogeneous and isotropic turbulence. Howe
ver, this equation is usually not verified in small to moderate Reynolds nu
mber flows. This is due partly to the lack of isotropy in either sheared or
non-sheared hows, and, more importantly, to the influence, which is flow s
pecific, of the inhomogeneous and anisotropic large scales. These shortcomi
ngs are examined in the context of the central region of a turbulent channe
l flow. In this case, we propose a generalized form of Kolmogorov's equatio
n, which includes some additional terms reflecting the large-scale turbulen
t diffusion acting from the walls through to the centreline of the channel.
For moderate Reynolds numbers, the mean turbulent energy transferred at a
scale r also contains a large-scale contribution, reflecting the non-homoge
neity of these scales. There is reasonable agreement between the new equati
on and hot-wire measurements in the central region of a fully developed cha
nnel flow.