Women report more intense, more numerous, and more frequent bodily symptoms
than men. This difference appears in samples of medical patients and in co
mmunity samples, whether or not gynecologic and reproductive symptoms are e
xcluded, and whether all bodily symptoms or only those which are medically
unexplained are examined. More limited, but suggestive, literature on exper
imental pain, symptom reporting in childhood, and pain thresholds in animal
s are compatible with these findings in adults. A number of contributory fa
ctors have been implicated, supported by varying degrees of evidence. These
include innate differences in somatic and visceral perception; differences
in symptom labeling, description, and reporting; the socialization process
, which leads to differences in the readiness to acknowledge and disclose d
iscomfort; a sex differential in the incidence of abuse and violence; sex d
ifferences in the prevalence of anxiety and depressive disorders; and gende
r bias in research and in clinical practice. General internists need to kee
p these factors in mind in obtaining the clinical history, understanding th
e meaning and significance that symptoms hold for each patient, and providi
ng symptom relief.