We report a case of Mycobacterium marinum infection in a lung transplant re
cipient who presented with nodules on the hand and forearm following exposu
re to fish-tank water of a superficial hand burn. Skin biopsy revealed gran
ulomatous inflammation and fibrosis. Tissue culture grew Mycobacterium mari
num. The patient underwent surgical excision of the lesions and treatment w
ith ethambutol and azithromycin for 12 months and experienced complete reso
lution of the infection. Transplant recipients who receive immunosuppressiv
e therapy are at increased risk for opportunistic infections. For a patient
with nodular lesions on the extremities, exposure to fish, fish-tank water
, or swimming should suggest infection with Mycobacterium marinum.