Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus

Authors
Parshikov, IA Freeman, JP Lay, JO Moody, JD Williams, AJ Beger, RD Sutherland, JB
Citation
Ia. Parshikov et al., Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus, J IND MIC B, 26(3), 2001, pp. 140-144
Citations number
20
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
13675435 → ACNP
Volume
26
Issue
3
Year of publication
2001
Pages
140 - 144
Database
ISI
SICI code
1367-5435(200103)26:3<140:MOTVFS>2.0.ZU;2-8
Abstract
To investigate the microbial biotransformation of veterinary fluoroquinolon es, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were a nalyzed by liquid chromatography. The two metabolites (26% and 15% of the A (280), respectively) were identified by mass and H-1 nuclear magnetic reson ance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin, The biological formation of desethylene-N-acetylsarafloxacin has not been p reviously observed.