Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onsetAlzheimer's disease

Objectives-The only locus unequivocally associated with late onset Alzheime r's disease (AD) risk is APOE. However, this locus accounts for less than h alf the genetic variance. A recent study suggested that the A allele of the 3'UTR biallelic polymorphism in the LBP-1clCP2lLSF gene was associated wit h reduced AD risk. Samples were diagnosed predominantly by clinical rather than pathological criteria. We have sought to replicate this finding in a s eries of necropsy confirmed, late onset AD cases and non-demented controls. Methods-The 3'UTR polymorphism in the LBP-1clCP2lLSF gene was typed in 216 necropsy confirmed AD cases and 301 non-demented controls aged >73 years. Results-We found different LBP-1clCP2l LSF allele distributions in our AD c ases and controls (p=0.048); the A allele was associated with reduced AD ri sk. The allele and genotype frequencies observed in our cases and controls were similar to those previously reported. No significant effects emerged w hen the data were adjusted for age, sex, or apoE epsilon4 carrier status. Conclusions-Our data support LBP-1clCP2lLSF as a candidate gene/risk factor for AD and provide justification for future studies to investigate the rol e of this gene in Alzheimer's disease.