Structural and functional images of the brain play an important role as pow
erful adjuncts in the management of an increasing number of neurologic and
psychiatric diseases. Brain SPECT, in particular, with perfusion agents or
with neuroreceptor imaging radiopharmaceuticals, is rapidly becoming a clin
ical tool in many places. For many neurologic and psychiatric conditions, t
his imaging modality has been used in diagnosis, prognosis assessment, eval
uation of response to therapy, risk stratification, detection of benign or
malignant viable tissue, and choice of medical or surgical therapy. The imp
ortance of this technique in nuclear medicine today should not be overlooke
d, particularly in cerebrovascular diseases, dementias, epilepsy, head inju
ry, malignant brain tumors, movement disorders, obsessive-compulsive disord
er, Gilles de la Tourette's syndrome, schizophrenia, depression. panic diso
rder, and drug abuse.