Hopelessness, loss of meaning, and existential distress are proposed as the
core features of the diagnostic category of demoralization syndrome. This
syndrome can be differentiated from depression and is recognizable in palli
ative care settings. it is associated with chronic medical illness, disabil
ity, bodily disfigurement, fear of loss of dignity, social isolation, and -
where there is a subjective sense of incompetence - feelings of greater de
pendency on others or the perception of being a burden. Because of the sens
e of impotence or helplessness, those with the syndrome predictably progres
s to a desire to die or to commit suicide. A treatment approach is describe
d which has the potential to alleviate the distress caused by this syndrome
. Overall, demoralization syndrome has satisfactory face, descriptive, pred
ictive, construct, and divergent validity, suggesting its utility as a diag
nostic category in palliative care.