Until recently waste production was seen as an inevitable outcome of indust
rial production and processing, and a problem that could be managed by end-
of-pipe and ill situ biotreatment, disposal, or simply be ignored. However
the introduction of clean, or cleaner, technology options now is focussing
attention on the minimisation of materials and energy use, and waste genera
tion, and upon recycle. Thus clean technology has emerged as a concept that
is compatible with industrial sustainability, and whose environmental bene
fits and economic competitiveness have been demonstrable over a range of in
dustrial sectors. Biotechnology is an enabling technology that offers one i
mportant route to clean products and processes; it provides powerful and ve
rsatile tools that can compete with chemical and physical means of reducing
both material and energy consumption, and tl-re generation of wastes and e
missions. The wide penetration of biotechnology in industry has still to oc
cur but many examples of its ability to deliver clean and competitive produ
cts and processes are now available particularly through the development an
d application of biocatalysts. The introduction of clean or cleaner process
ing does not necessarily entail a complete change in manufacturing strategy
or the refitting of plant. Upgrading existing manufacturing processes by f
itting biotechnology unit stages illustrates the opportunities for such int
ermediate technology. Nevertheless, for biotechnology to achieve its full p
otential as a basis for clean industrial products and processes beyond its
current applications, innovative R&D will be needed. The successful applica
tion of biotechnology as a clean technology is illustrated in this review t
hrough a series of case studies, while the innovative nature of biotechnolo
gy in this context is demonstrated by the development and application of no
vel biocatalysts.