A phantom with tissue-like optical properties in the visible and near infrared for use in photomedicine

Background and Objective: Modeling of light transport in tissue requires de velopment of theoretical models and experimental procedures, as well as tis sue-simulating phantoms. Our purpose was to develop a phantom that matches the optical characteristics of human skin in the visible and near infrared spectral range. Study Design/Materials and Methods: The phantom consists of a transparent s ilicone rubber in which Al2O3 particles and a cosmetic powder are embedded. Layers with thickness as thin as 0.1 mm can be made. The optical propertie s of Al2O3 particles and cosmetic powder, i.e., total attenuation, absorpti on and scattering coefficients, and phase function, have been determined in the visible and near infrared spectral range, by using direct and indirect techniques. Results: By varying the concentration of scattering and absorbing particles , tissue-like layers can be produced with predictable optical properties. I n particular, mixing at suitable concentration Al2O3 particles and cosmetic powder with the silicone rubber, the optical properties of human skin have been simulated over a range of wavelengths from 400 to 1,000 nm. The compa rison between the phantom diffuse reflectance spectrum and that of human sk in, averaged over a sample of 260 patients, showed a good agreement. Conclusion: The proposed technique allows to produce a stable and reproduci ble phantom, with accurately predictable optical properties, easy to make a nd to handle. This phantom is a useful tool for numerous applications invol ving light interaction with biologic tissue. (C) 2001 Wiley-Liss, Inc.