Citation
A. Zabala et al., Anti-proliferative effect of two lactic acid bacteria strains of human origin on the growth of a myeloma cell line, LETT APPL M, 32(4), 2001, pp. 287-292
Citations number
19
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
LETTERS IN APPLIED MICROBIOLOGY
ISSN journal
02668254
→ ACNP
Volume
32
Issue
4
Year of publication
2001
Pages
287 - 292
Database
ISI
SICI code
0266-8254(200104)32:4<287:AEOTLA>2.0.ZU;2-7
Abstract
Aims: Twenty lactic acid bacteria strains were isolated from human faeces a
nd tested by MTT assay for stimulation or inhibition of the proliferation o
f Vero and myeloma cells.
Methods and Results: None of the strains significantly affected the prolife
ration of Vero cells. However, two isolates (HN1 and HA8) showed a strong i
nhibition of myeloma cell proliferation (16.7 and 5.0%, respectively) bq MT
T assay.
Conclusions: Both strains have an anti-proliferative effect on a tumoral ce
ll line.
Significance and Impact of the Study: The beneficial effect of LAB cancer t
herapy has been linked to their ability for immunomodulation.