Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non-small cell lung cancer

The combination of paclitaxel and etoposide was evaluated in a phase II stu dy in patients with locally advanced or metastatic non small-cell lung canc er (NSCLC). Thirty-five patients, median age 61, received treatment with pa clitaxel 200 mg/m(2) intravenous over 3 h on day 1, and oral etoposide, 100 mg daily on days 1-5. Cycles were repeated every 21 days for a maximum of nine cycles, or until progression occurred. Twenty-eight patients bad stage IV disease, and seven patients had stage IIIA or B disease. There was one complete and seven partial responses (overall response rate? 23%). Two of t hese responses were in patients with stage III disease (29%) and six in pat ients with stage IV disease (21%). Median survival was 8.7 months, and 36% of patients were alive at 1 year. There were no treatment-related deaths an d tittle grade 3 or 4 non-haematological toxicity although grade 3 or 4 neu tropenia occurred in 60% of patients (33% of cycles). There were four episo des of febrile neutropenia. The combination of paclitaxel and oral etoposid e is active in advanced NSCLC and can be delivered with acceptable toxicity . (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.