Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer

Authors
Chizhikov, V Zborovskaya, I Laktionov, K Delektorskaya, V Polotskii, B Tatosyan, A Gasparian, A
Citation
V. Chizhikov et al., Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer, MOL CARCINO, 30(3), 2001, pp. 151-158
Citations number
26
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
MOLECULAR CARCINOGENESIS
ISSN journal
08991987 → ACNP
Volume
30
Issue
3
Year of publication
2001
Pages
151 - 158
Database
ISI
SICI code
0899-1987(200103)30:3<151:TCDRWC>2.0.ZU;2-P
Abstract
Allelic losses at 1 p32-pter have been reported as frequent events in human non-small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissect ed NSCLC samples with 20 polymorphic markers spanning 1 p32-pter. Two short est regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S4 17-D1S57) and SRO 2b (D1S450-D1S243), Allelic losses at either region corre lated independently with advanced stage of disease and with postoperative m etastasis and relapse (P<0.05), suggesting that crucial genes in these regi ons are involved in NSCLC progression. <(c)> 2001 Wiley-Liss. Inc.