The potential of nucleic acid repair in functional genomics

Authors
Rice, MC Czymmek, K Kmiec, EB
Citation
Mc. Rice et al., The potential of nucleic acid repair in functional genomics, NAT BIOTECH, 19(4), 2001, pp. 321-326
Citations number
48
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
NATURE BIOTECHNOLOGY
ISSN journal
10870156 → ACNP
Volume
19
Issue
4
Year of publication
2001
Pages
321 - 326
Database
ISI
SICI code
1087-0156(200104)19:4<321:TPONAR>2.0.ZU;2-F
Abstract
Chimeric RNA/DNA oligonucleotides have been used successfully to correct po int and frameshift mutations in cells as well as in animal and plant models . This approach is one of several nucleic acid repair technologies that wil l help elucidate the function of newly discovered genes. Understanding the mechanisms by which these different technologies direct gene alteration is essential for progress in their application to functional genomics.