Differentiation or leukemia: Is C/EBP alpha the answer?

Authors
Hiebert, S
Citation
S. Hiebert, Differentiation or leukemia: Is C/EBP alpha the answer?, NAT MED, 7(4), 2001, pp. 407-408
Citations number
10
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
7
Issue
4
Year of publication
2001
Pages
407 - 408
Database
ISI
SICI code
1078-8956(200104)7:4<407:DOLICA>2.0.ZU;2-1
Abstract
Acute myelogenous leukemias are caused by point mutations as well as severa l different types of chromosomal translocations, but little is known about how these genetic defects lead to disruptions in hematopoiesis and eventual leukemogenesis. Two recent studies suggest that the resulting mutant gene products can alter function of the transcription factor C/EBP alpha and tip the balance from differentiation toward cancer (pages 444-451).