A 2 '-acylamido cap that increases the stability of oligonucleotide duplexes

Authors
Kryatova, OP Connors, WH Bleczinski, CF Mokhir, AA Richert, C
Citation
Op. Kryatova et al., A 2 '-acylamido cap that increases the stability of oligonucleotide duplexes, ORG LETT, 3(7), 2001, pp. 987-990
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
7
Year of publication
2001
Pages
987 - 990
Database
ISI
SICI code
1523-7060(20010405)3:7<987:A2'CTI>2.0.ZU;2-L
Abstract
Reported here is the synthesis of oligonucleotides containing a 2'-acyiamid o-2' deoxyuridine residue at their 3'-terminus. Compared to control sequenc es bearing a thymidine residue, the quinolone-capped duplexes give higher U V melting points. In the case of (5'-ACGCGU-NA-2')(2), where NA denotes a n alidixic acid residue, the melting point increase is up to 22 degreesC over that of (ACGCGT)(2).