Stimulatory and protective effects of alkylating agents applied in ultra-low concentrations

Alkylating drugs belonging to the nitrogen mustard family are known as cyto static and immunosuppressive agents. Ultra-low doses of these drugs may dem onstrate pharmacological effects unlike this category of drugs. In the case of a gradual dose decrease, the number of targets for alkylation is also r educed and the drug switches from cytostatic to cell growth modifier. We po stulate that application of ultra-low doses of alkylating drugs may result in a beneficial effect in the therapy of diseases associated with chronic i nflammation of the mucosa, especially with the signs of epithelial atrophy. Copyright (C) 2001 S. Karger AG, Basel.