Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme

Authors
Gobec, S Urleb, U Auger, G Blanot, D
Citation
S. Gobec et al., Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme, PHARMAZIE, 56(4), 2001, pp. 295-297
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
56
Issue
4
Year of publication
2001
Pages
295 - 297
Database
ISI
SICI code
0031-7144(200104)56:4<295:SABEOS>2.0.ZU;2-M
Abstract
A series of N-(5-phthalimidopentanoyl)-, N-[2-(2-ethoxy)acetyl]-, and N-(7- oxooctanoyl)-phosphuno and phosphinoalanine derivatives has been synthesize d and evaluated for inhibition of the D-glutamic acid-adding enzyme (MurD) of peptidoglycan biosynthesis.