The quantum mechanical formula for Mayer's second cluster integral for the
gas of relativistic particles with hard-core interaction is derived. The pr
oper pion volume calculated with quantum mechanical formula is found to be
an order of magnitude larger than its classical evaluation. The second clus
ter integral for the pion gas is calculated in quantum mechanical approach
accounting for both attractive and hard-core repulsive interactions. It is
shown that, in the second cluster approximation, the repulsive pi pi -inter
actions as well as the finite width of resonances give important but almost
canceling contributions. In contrast, an appreciable deviation from the id
eal gas of pions and pion resonances is observed beyond the second cluster
approximation in the framework of the Van der Waals excluded-volume model.