Withanolide-type steroids from Solanum cilistum

Six withanolide-type steroids, named as cilistols a, b, d, q, g and f, resp ectively, were isolated from the leaves of Solanum cilistum. The major comp onent among them, cilistol a, was characterized as (22R, 24S, 25R, 26R)-1-o xo-22, 26; 24, 25-diepoxy-17 alpha, 26-dihydroxyergost-2,5-diene on the bas is of spectrescopic properties and X-ray crystallographic analysis; the oth er isolated compounds had closely related structures. This is the first rep ort of withanolide-type steroids in the Solanum genera. (C) 2001 Elsevier S cience Ltd. All rights reserved.