A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography

Authors
Qiu, SX van Hung, N Xuan, LT Gu, JQ Lobkovsky, E Khanh, TC Soejarto, DD Clardy, J Pezzuto, JM Dong, YM Van Tri, M Huong, L Fong, HHS
Citation
Sx. Qiu et al., A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography, PHYTOCHEM, 56(7), 2001, pp. 775-780
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
56
Issue
7
Year of publication
2001
Pages
775 - 780
Database
ISI
SICI code
0031-9422(200104)56:7<775:APSFAL>2.0.ZU;2-7
Abstract
The pregnane steroid, (E)-aglawone, along with four known triterpenes, and a known sterol mixture were isolated from the bark of Aglaia lawii (Wight) Saldanha ex Ramamoorty (Meliaceae). The structural determination/identifica tion was accomplished by a combination of 1D- and 2D-NMR spectroscopic tech niques. The relative stereochemistry of the known triterpene, 20S,24S-epoxy dammarane-3 alpha ,25-diol acetate, was also unequivocally determined for t he first lime by X-ray crystallography. The isolates were not active agains t Various human cancer cell lines. (C) 2001 Elsevier Science Ltd. All right s reserved.