Lipotoxicity and glucotoxicity in type 2 diabetes - Effects on developmentand progression

Authors
Sivitz, WI
Citation
Wi. Sivitz, Lipotoxicity and glucotoxicity in type 2 diabetes - Effects on developmentand progression, POSTGR MED, 109(4), 2001, pp. 55
Citations number
24
Categorie Soggetti
General & Internal Medicine
Journal title
POSTGRADUATE MEDICINE
ISSN journal
00325481 → ACNP
Volume
109
Issue
4
Year of publication
2001
Database
ISI
SICI code
0032-5481(200104)109:4<55:LAGIT2>2.0.ZU;2-W
Abstract
Lipotoxicity and glucotoxicity may both be implicated in the pathogenesis o f type 2 diabetes. Excess circulating fat, glucose, or both act on diverse cells and tissues to counteract insulin-mediated glucose uptake, hepatic re gulation of glucose output, and insulin secretion. In this article, Dr Sivi tz reviews the biochemistry and clinical implications of these conditions a nd how to manage them through lifestyle modifications.