A common observation: Ketoprofene gels, widely used to treat benign conditi
ons, can provoke local intolerance. The most commonly reported clinical fea
tures include eczema, sometimes severe acute contact photoallergy that ofte
n spread beyond the site of application and may even lead to a long-duratio
n generalized reaction.
Diagnosis: Photoallergological tests allow positive diagnosis of the ketopr
ofene-induced contact photosensitization and underline the role of the benz
ophenone ring, explaining certain cross allergies with fenofibrate and oxyb
enzone.
Precautions for use: The primary rule is to avoid sun exposure, requiring b
etter information for prescribers and patients.