Objectives: To evaluate the differences between two cohorts of patients wit
h severe mental illness (schizophrenia-spectrum or bipolar disorder) and co
-occurring substance-use disorders, living in either predominantly rural ar
eas or urban areas. Methods: Two study groups of patients with a dual diagn
osis, recruited using the same criteria, were evaluated, including 225 pati
ents from New Hampshire and 166 patients from two cities in Connecticut. Th
e two study groups were compared on demographic characteristics, housing, l
egal problems, psychiatric and substance use diagnoses, substance use and a
buse, psychiatric symptoms, and quality of life. Results: Patients in the C
onnecticut study group had higher rates of cocaine-use disorder, more invol
vement in the criminal justice system, more homelessness, and were more lik
ely to be from minority backgrounds. The Connecticut group also had a highe
r proportion of patients with schizophrenia and more severe symptoms, as we
ll as lower rates of marriage, educational attainment, and work than the Ne
w Hampshire study group. Alcohol-use disorder was higher in the New Hampshi
re group. Subsequent analyses within the Connecticut group indicated that a
lthough African American patients had higher rates of cocaine-use disorder
than white patients, cocaine disorder and not minority status was most stro
ngly related to criminal involvement and homelessness. Conclusions: Because
of the substances abused and the greater degree of psychiatric illness sev
erity, patients with a dual diagnosis who are living in urban areas may req
uire greater ancillary services, such as residential programs, Assertive Co
mmunity Treatment, and jail diversion programs in order to treat their diso
rders successfully. (C) 2001 Elsevier Science B.V. All rights reserved.