Crawling and wiggling on DNA: Structural insights to the mechanism of DNA unwinding by helicases

Authors
Marians, KJ
Citation
Kj. Marians, Crawling and wiggling on DNA: Structural insights to the mechanism of DNA unwinding by helicases, STRUCTURE, 8(12), 2000, pp. R227-R235
Citations number
31
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE
ISSN journal
09692126 → ACNP
Volume
8
Issue
12
Year of publication
2000
Pages
R227 - R235
Database
ISI
SICI code
0969-2126(200012)8:12<R227:CAWODS>2.0.ZU;2-9
Abstract
Crystal structures have recently been solved of the monomeric DNA helicase PcrA bound to forked DNA, and of the hexameric helicase domain of the bacte riophage T7 gene 4 protein, a replication fork DNA helicase/primase. These structures have led to the elaboration of the first molecular models to des cribe DNA helicase action.