DNA mismatch repair: The hands of a genome guardian

Authors
Hopfner, KP Tainer, JA
Citation
Kp. Hopfner et Ja. Tainer, DNA mismatch repair: The hands of a genome guardian, STRUCTURE, 8(12), 2000, pp. R237-R241
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE
ISSN journal
09692126 → ACNP
Volume
8
Issue
12
Year of publication
2000
Pages
R237 - R241
Database
ISI
SICI code
0969-2126(200012)8:12<R237:DMRTHO>2.0.ZU;2-4
Abstract
DNA mismatch repair (MMR) is initiated when the MutS protein recognizes dam aged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA sh ow how MutS distinguishes damaged from undamaged DNA and explain how a broa d variety of DNA mismatch lesions can be detected. The structures suggest m echanisms for the ATP-induced structural regulation of multistep DNA repair processes.