Structure and mechanism of homoserine kinase: Prototype for the GHMP kinase superfamily

Authors
Zhou, T Daugherty, M Grishin, NV Osterman, AL Zhang, H
Citation
T. Zhou et al., Structure and mechanism of homoserine kinase: Prototype for the GHMP kinase superfamily, STRUCTURE, 8(12), 2000, pp. 1247-1257
Citations number
61
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE
ISSN journal
09692126 → ACNP
Volume
8
Issue
12
Year of publication
2000
Pages
1247 - 1257
Database
ISI
SICI code
0969-2126(200012)8:12<1247:SAMOHK>2.0.ZU;2-L
Abstract
Background: Homoserine kinase (HSK) catalyzes an important step in the thre onine biosynthesis pathway. It belongs;to a large yet unique class of small metabolite kinases, the GHMP kinase superfamily. Members in the GHMP super family participate in several essential metabolic pathways, such as amino a cid biosynthesis, galactose metabolism, and the mevalonate pathway.