A novel synthesis of beta-sulfinyl- and beta-sulfonyl-hydroxamic acids viaCsF-mediated ring opening of substituted beta-lactones

Authors
Rosse, G Gerber, F Specklin, JL Hubschwerlen, C
Citation
G. Rosse et al., A novel synthesis of beta-sulfinyl- and beta-sulfonyl-hydroxamic acids viaCsF-mediated ring opening of substituted beta-lactones, SYNLETT, (4), 2001, pp. 538-540
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
4
Year of publication
2001
Pages
538 - 540
Database
ISI
SICI code
0936-5214(200104):4<538:ANSOBA>2.0.ZU;2-Q
Abstract
The ring-opening reaction of 3-substituted beta -lactones with thiols was a chieved using CsF in DMF as promoter. The resulting beta -sulfanyl-carboxyl ic acid intermediates were coupled to hydroxylamine-Wang resin and the sulf ur atom was selectively oxidized to afford beta -sulfinyl- and beta -sulfon yl-hydroxamic acid libraries.