Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity

Authors
Tanaka, R Nagatsu, A Mizukami, H Ogihara, Y Sakakibara, J
Citation
R. Tanaka et al., Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity, TETRAHEDRON, 57(15), 2001, pp. 3005-3012
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
15
Year of publication
2001
Pages
3005 - 3012
Database
ISI
SICI code
0040-4020(20010409)57:15<3005:SOCMOM>2.0.ZU;2-A
Abstract
Monensin (1), an ionophore antibiotic agent, was converted to 25-carboxymon ensin (2) and 7-O-substituted-25-carboxyl derivatives (3a-d), which have tw o carboxyl groups at both ends of the molecule. Ca2+ ion transport activity of the dicarboxylic monensins was evaluated by the CHCl3 liquid membrane m ethod, and 25-carboxymonensins (2 and 3a-d) were shown to transport the Ca2 + ion through the CHCl3 liquid membrane. (C) 2001 Elsevier Science Ltd. All rights reserved.