The 1st percutaneous transluminal angioplasty marked a new era in the treat
ment of peripheral atherosclerotic lesions. The early techniques used in pe
ripheral percutaneous transluminal angioplasty form the basis for subsequen
t percutaneous intervention both in the peripheral and coronary arteries an
d are largely the contribution of Charles Dotter. Dotter was the 1st to des
cribe flow-directed balloon catheterization, the double-lumen balloon cathe
ter, the safety guidewire, percutaneous arterial stenting, and more. This p
ractical genius dedicated his considerable energy to the belief that there
is always a better way to treat disease. His personal contributions to clin
ical medicine, research, and teaching have saved millions of limbs and live
s all over the world.