HLA class I and class II allele and haplotype diversity in Martinicans

Citation
O. Bera et al., HLA class I and class II allele and haplotype diversity in Martinicans, TISSUE ANTI, 57(3), 2001, pp. 200-207
Citations number
20
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
57
Issue
3
Year of publication
2001
Pages
200 - 207
Database
ISI
SICI code
0001-2815(200103)57:3<200:HCIACI>2.0.ZU;2-H
Abstract
The Martinican population is mainly the product of admixture between Africa n people and French Caucasians. The aim of the present study is to investig ate at the DNA level the polymorphism of HLA class I (HLA-A, HLA-B) and cla ss II (HLA-DRB1, DQB1 and DPB1) genes in a population of 100 Martinicans. A llelic distributions and interlocus linkage disequilibria were compared to those observed in a French Caucasian population and in African or North Ame rican African populations. Our data revealed a higher degree of polymorphis m in Martinicans than in Caucasians and showed a prominant contribution of African origin in the admired genetic feature of this population. African c haracteristic alleles were significantly represented in Martinicans : A*30, *33 *34, *66, *74, *8001, B*1510, *35. *42, *53, DRB1*0302, *0804, *1202, *1304, *1503, DPB1*0101, *1701, *1801, *3901. Moreover a higher diversity o f A*-B* and DRB1*-DQB1* associations was observed in Martinicans compared t o Caucasians which also reflects the African genetic background of this pop ulation. In the whole. using PCR-based genotyping methods for HLA class I a nd class II loci, this study allows a preliminary description of HLA allele distribution in this Caribbean island and gives new elements which may be helpful in the anthropologic field as well as in HLA and disease associatio n studies.