Protein hydrolysates constitute an alternative to intact proteins and eleme
ntal formulas in the development of special formulations designed to provid
e nutritional support to patients with different needs. The production of e
xtensive protein hydrolysates by sequential action of endopeptidases and ex
oproteases coupled with the development of post hydrolysis procedures is co
nsidered the most effective way to obtain protein hydrolysates with defined
characteristics. This paper reviews the development and use of protein hyd
rolysates for dietary treatment of patients with phenyl-ketonuria, food all
ergy and chronic liver failure. (C) 2001 Published by Elsevier Science Ltd.
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