Evaluation of a low-invasive strategy for prostate cancer screening with prostate-specific antigen

Citation
M. Barette et al., Evaluation of a low-invasive strategy for prostate cancer screening with prostate-specific antigen, UROLOGY, 57(4), 2001, pp. 712-716
Citations number
23
Categorie Soggetti
Urology & Nephrology
Journal title
UROLOGY
ISSN journal
00904295 → ACNP
Volume
57
Issue
4
Year of publication
2001
Pages
712 - 716
Database
ISI
SICI code
0090-4295(200104)57:4<712:EOALSF>2.0.ZU;2-J
Abstract
Objectives. To evaluate a two-step strategy for the detection of prostate c ancer within the context of serial screening and compare this strategy with other screening strategies. The optimal combination of tests proposed for prostate cancer screening remains undetermined, particularly when screening is repeated over time. Methods. A prospective serial prostate cancer screening study with follow-u p to 55 months was performed in a general community screening clinic. One t housand seven hundred seven self-referred men, 50 to 75 years old, without a history of prostate cancer agreed to undergo screening for prostate cance r on an annual basis. Serum prostate-specific antigen (PSA) measurement was the first-step screening test. If the serum PSA test was positive, a stand ard urologic evaluation was performed. Biopsy was recommended only if a tes t other than serum PSA was suspicious for cancer. The outcome measures were the biopsy rate and prostate cancer detection rate. The comparisons with o ther studies were age-standardized to correct for differences in age distri bution. Results. The biopsy and cancer detection rates after the first test were 7. 0% and 2.0%, respectively. After 4 years of the study, the cumulative biops y rate and cumulative cancer detection rate per enrolled man was 12% and 4. 1%, respectively. The comparisons between studies revealed that screening s trategies using serum PSA as a first-line test had similar detection rates but lower biopsy rates than strategies performing biopsy when one of severa l screening tests was positive. Conclusions, A two-step screening strategy using serum PSA alone as the ini tial test seemed able to detect as many cancers as when all screening tests were used at the same time but reduced the number of unnecessary biopsies. UROLOGY 57: 712-716, 2001. (C) 2001, Elsevier Science Inc.