This article reviews some of the issues surrounding antimicrobial use in tr
eating diseases that cause lameness in cattle. The discussion includes sect
ions on selection of an antimicrobial, regimen design, and medication of mu
ltiple animals. Pathogen susceptibility tasting is covered, along with empi
ric selection of antimicrobials. Other issues covered include regional perf
usion and topical application of antimicrobials, antimicrobials in footbath
s and in feed, and withdrawal time estimates.