Benzyl tert-butoxycarbonyl-alpha-amino-isobutyrate

Authors
Leduc, AM Mashuta, MS Spatola, AF
Citation
Am. Leduc et al., Benzyl tert-butoxycarbonyl-alpha-amino-isobutyrate, ACT CRYST C, 57, 2001, pp. 487-488
Citations number
11
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
57
Year of publication
2001
Part
4
Pages
487 - 488
Database
ISI
SICI code
0108-2701(20010415)57:<487:BT>2.0.ZU;2-0
Abstract
The small synthetic peptide, benzyl 2-(tert-butoxycarbonylamino)isobutyrate , C16H23NO4, has the alpha -helical conformation [\ phi \ = 55.8 (2)degrees and \ psi \ = 37.9 (2)degrees] observed in peptide fragments of peptaibols containing the alpha -aminoisobutyric acid (Aib) residue. The structure sh ows no intramolecular hydrogen bonding, which would disrupt the limited con formational freedom associated with this amino acid. Two weak intermolecula r hydrogen contacts are observed.