Rh. Muller et al., Nanosuspensions as particulate drug formulations in therapy Rationale for development and what we can expect for the future, ADV DRUG DE, 47(1), 2001, pp. 3-19
An increasing number of newly developed drugs are poorly soluble: in many c
ases drugs are poorly soluble in both aqueous and organic media excluding t
he traditional approaches of overcoming such solubility factors and resulti
ng in bioavailability problems. An alternative and promising approach is th
e production of drug nanoparticles (i.e. nanosuspensions) to overcome these
problems. The major advantages of this technology are its general applicab
ility to most drugs and its simplicity. In this article, the production of
nanoparticles on a laboratory scale is presented, special features such as
increased saturation solubility and dissolution velocity are discussed, and
special applications are highlighted, for example, mucoadhesive nanosuspen
sions for oral delivery and surface-modified drug nanoparticles for sire-sp
ecific delivery to the brain. The possibilities of large scale production -
the prerequisite for the introduction of a delivery system to the market a
re also discussed. (C) 2001 Elsevier Science B.V. All rights reserved.