Depression and disability in late life - Directions for future research

The author reviews evidence from epidemiologic and clinical studies suggest ing a reciprocal, potentially spiraling, relationship between depression an d disability in older adults. The discussion outlines possible methodologic al and conceptual explanations for this evidence and poses avenues for futu re research. An underlying theme is the impact of how disability and depres sion are measured on the nature of empirical evidence and its interpretatio n. Measures and corresponding analytic strategies that capture the complexi ty of depression, disability, and their relationship are expected to lead t o the most fruitful approaches to reducing the burden of depression and dis ability in the lives of older adults.