Birth weight and parental PGM1 alleles

A deviation of the maternal-neonatal joint phosphoglucomutase locus 1 (PGM1 ) distribution from Hardy-Weinberg expectation has been reported. It was su ggested that selection on PGM1 during intrauterine life might account for t hese deviations and that maternal and paternal PGM1 alleles might have diff erent associations with intrauterine survival. This study considered possib le associations between the joint mother-newborn PGM1 genotype and intraute rine growth. There was a significant association between birth weight perce ntile class and mother-newborn PGM1 genotype in infant females. Also, the p aternal PGM1*2 allele was associated negatively with macrosomia, and this e ffect was significant only in female infants. (C) 2001 Wiley-Liss, Inc.