LINEAGE AND FATE IN DROSOPHILA - ROLE OF THE GENE TRAMTRACK IN SENSE ORGAN DEVELOPMENT

The tactile bristles of the fly comprise four cells that originate fro m a single precursor cell through a fixed lineage. The gene tramtrack (ttk) plays a crucial role in defining the fates of these cells. Here we analyse the normal pattern of expression of ttk, as well as the eff ect of ttk overexpression at different steps of the lineage. We show t hat ttk is never expressed in cells having a neural potential, and tha t in cells where ttk is expressed, there is a delay between division a nd the onset of expression. The ectopic expression of ttk before some stage of the cell cycle can block further cell division. Furthermore, this expression transforms neural into nonneural cells, suggesting tha t ttk acts as a repressor of neural fate at each step of the lineage. Our results suggest that ttk is probably not involved in setting up th e mechanism that creates an asymmetry between sister cells, but rather in the implementation of that choice.