High-fat hypocaloric diet modifies carbohydrate utilization of obese rats during weight loss

Citation
Mc. Cha et al., High-fat hypocaloric diet modifies carbohydrate utilization of obese rats during weight loss, AM J P-ENDO, 280(5), 2001, pp. E797-E803
Citations number
36
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
ISSN journal
01931849 → ACNP
Volume
280
Issue
5
Year of publication
2001
Pages
E797 - E803
Database
ISI
SICI code
0193-1849(200105)280:5<E797:HHDMCU>2.0.ZU;2-Y
Abstract
The effects of fat content in the hypocaloric diet on whole body glucose ox idation and adipocyte glucose transport were investigated in two animal-fee ding experiments. Diet-induced obese rats were food restricted to 75% of th eir previous energy intakes with either a high (45% by calorie) or a low (1 2% by calorie) corn oil diet for 9 wk (experiment 1) or 10 days (experiment 2). The losses of body weight (P < 0.05) and adipose depot weight (P < 0.0 5) were less in the 45% compared with the 12% fat group. During the dynamic phase of weight loss (day 10 of food restriction), plasma glucose and insu lin concentrations were higher (P < 0.05) in the 45% than those in the 12% fat group. Whole body carbohydrate oxidation rate in response to an oral lo ad of glucose was increased (P < 0.001) by food restriction in both dietary groups; however, carbohydrate oxidation rates were lower (P < 0.01) in the 45% than in the 12% fat-fed rats during the weight loss period. Adipocyte glucose transport was greater (P < 0.02) in the 45% than in the 12% fat gro up in an intra-abdominal adipose depot but not in subcutaneous fat. These d ata suggest that dietary fat content modifies whole body glucose oxidation and intra-abdominal adipocyte glucose uptake during weight loss.