Enantioselective separation of epoxides by capillary electrophoresis employing sulfated beta-cyclodextrin as chiral selector

A capillary electrophoresis method was developed for the enantioseparation of epoxide compounds. Sulfated beta -cyclodextrin was employed as a chiral selector. Phosphate-triethanalamine buffer showed a chiral separation effec t when employing charged sulfated beta -cyclodextrin. The effect of pH, tri ethanolamine concentration and sulfated beta -cyclodextrin concentration on the resolution was studied. Methanol was tested as an organic modifier. Se veral other epoxides were successfully separated by the proposed method.