BIOLOGICAL-ACTIVITIES OF PSEUDOMYCIN-A, A LIPODEPSINONAPEPTIDE FROM PSEUDOMONAS-SYRINGAE MSU 16H

Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A in hibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythro cytes, affects H+-ATPase activity and proton translocation in plasma m embrane vesicles, and stimulates succinate respiration in pea mitochon dria. In general, the biological activities of pseudomycin A are lower than those of syringomycin-E, the prototype member of this family of bacterial metabolites. This difference might depend on the diverse num ber and distribution of charged residues in the peptide moiety of thes e compounds. (C) 1997 Elsevier Science Ltd. All rights reserved.