COUMARINS AND ANTI-HBV CONSTITUENTS FROM ZANTHOXYLUM-SCHINIFOLIUM

Continuing examination on the chloroform-soluble part of the bark of Z anthoxylum schinifolium, two new terpenyl coumarins, droxy-3',7'-dimet hylocta-2',7'-dienyloxy)-coumarin and hyl-3'-methyleneocta-7'enyloxy)- 8-methoxycoumarin, along with three coumarins, anisocoumarin H, roxy-3 ',7'-dimethylocta-2',5'-dienyloxy]-coumarin, scopoletin; two alkaloids , 4-methoxy-1-methyl-2-quinolone and oxynitidine and a lignan, (+)-mat airesinol, were isolated as additional constituents. The structures of these compounds were elucidated by spectral analyses. Among the isola tes of the bark, collinin and oxynitidine showed significant activity of anti-HBV DNA replication. (C) 1997 Elsevier Science Ltd. All rights reserved.