Wm. Mounts et Mn. Liebman, QUALITATIVE MODELING OF NORMAL BLOOD-COAGULATION AND ITS PATHOLOGICALSTATES USING STOCHASTIC ACTIVITY NETWORKS, International journal of biological macromolecules, 20(4), 1997, pp. 265-281
We have developed a method for representing biological pathways and si
mulating their behavior based on the use of stochastic activity networ
ks (SANs). SANs, an extension of the original Petri net, have been use
d traditionally to model flow systems including data-communications ne
tworks and manufacturing processes. We apply the methodology to the bl
ood coagulation cascade, a biological flow system, and present the rep
resentation method as well as results of simulation studies based on p
ublished experimental data. In addition to describing the dynamic mode
l, we also present the results of its utilization to perform simulatio
ns of clinical slates including hemophilia's A and B as well as sensit
ivity analysis of individual factors and their impact on thrombin prod
uction. (C) 1997 Elsevier Science B.V.