CONVENIENT AND STEREOSPECIFIC HOMOLOGATION OF N-FLUORENYL-METHOXYCARBONYL-ALPHA-AMINO ACIDS TO THEIR BETA-HOMOLOGS

Authors
LEGGIO A LIGUORI A PROCOPIO A SINDONA G
Citation
A. Leggio et al., CONVENIENT AND STEREOSPECIFIC HOMOLOGATION OF N-FLUORENYL-METHOXYCARBONYL-ALPHA-AMINO ACIDS TO THEIR BETA-HOMOLOGS, Journal of the Chemical Society. Perkin transactions. I, (13), 1997, pp. 1969-1971
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
13
Year of publication
1997
Pages
1969 - 1971
Database
ISI
SICI code
0300-922X(1997):13<1969:CASHON>2.0.ZU;2-Z
Abstract
A very simple approach to the enantioselective homologation of alpha-a mino acids is presented which is based on the formation of N-Fmoc-amin oacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting grou p in the overall transformation.