Crossed unilateral lesions of medial forebrain bundle and either inferior temporal or frontal cortex impair object recognition memory in Rhesus monkeys

Citation
A. Easton et al., Crossed unilateral lesions of medial forebrain bundle and either inferior temporal or frontal cortex impair object recognition memory in Rhesus monkeys, BEH BRA RES, 121(1-2), 2001, pp. 1-10
Citations number
36
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BEHAVIOURAL BRAIN RESEARCH
ISSN journal
01664328 → ACNP
Volume
121
Issue
1-2
Year of publication
2001
Pages
1 - 10
Database
ISI
SICI code
0166-4328(200106)121:1-2<1:CULOMF>2.0.ZU;2-F
Abstract
In monkeys, section of the fornix, amygdala and anterior temporal stem resu lts in a severe anterograde amnesia. Immunolesions of the cholinergic cells of the basal forebrain suggest that this amnesia is a result of isolating the inferior temporal cortex and medial temporal lobe from their cholinergi c basal forebrain afferents. In this experiment. six monkeys were trained i n a delayed match-to-sample task and then received a section of the medial forebrain bundle in one hemisphere and an ablation of either the frontal or inferior temporal cortex in the opposite hemisphere. All the animals were severely impaired in the performance of this task following this surgery, a nd the severity of the impairment was independent of the cortical area from which the medial forebrain bundle was disconnected. These results support a model of fronto-temporal interaction via the basal forebrain in new learn ing, in which midbrain sites related to reward modulate the cholinergic bas al forebrain activity. (C) 2001 Elsevier Science B.V. All rights reserved.