3 COMPONENT AMINOALKYLATION OF ALDEHYDES BY FUNCTIONALIZED ORGANOZINCCOMPOUNDS PROMOTED BY LITHIUM PERCHLORATE (LICLO4)

Authors
SAIDI MR KHALAJI HR IPAKTSCHI J
Citation
Mr. Saidi et al., 3 COMPONENT AMINOALKYLATION OF ALDEHYDES BY FUNCTIONALIZED ORGANOZINCCOMPOUNDS PROMOTED BY LITHIUM PERCHLORATE (LICLO4), Journal of the Chemical Society. Perkin transactions. I, (13), 1997, pp. 1983-1986
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
13
Year of publication
1997
Pages
1983 - 1986
Database
ISI
SICI code
0300-922X(1997):13<1983:3CAOAB>2.0.ZU;2-B
Abstract
The one-pot synthesis of several N,N-dialkylamino esters is reported. Treatment of aldehydes 1 (aliphatic and aromatic) with (trimethylsilyl )dialkylamines 2, in the presence of LiClO4 in diethyl ether presumabl y gives the intermediates 3. Reaction of these intermediates 3 with fu nctionalized organozinc reagents, RZnBr, produces a variety of N,N-dia lkylamino esters in a short time (about 1 h) and in good to moderate y ields. The pure products are isolated by extraction with cold hydrochl oric acid.